Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier. (January 2019) - Hung, Tran Van
Graphical abstract: Highlights: Oral leucosaccharides mitigate adenine-induced renal failure in mice. Leucosaccharides reinforce intestinal barriers by restoring healthful microbiota. Leucosaccharides prevent uremia, endotoxemia, inflammation, and fibrosis. Leucosaccharides may also prevent complications such as atherosclerosis. Abstract: Feeding with 10% leucosaccharides for 3 weeks mitigated the development of adenine-induced chronic kidney disease in mice, as assessed by plasma urea, renal expression of inflammatory- and fibrosis-associated molecules, and colonic expression of tight junction proteins. Leucosaccharides are exopolysaccharides produced by Leuconostoc mesenteroides subsp. mesenteroides strain NTM048. Sequencing of 16S rRNA also revealed that leucosaccharides reverse the accumulation of Desulfovibrionaceae and Bifidobacterium and the loss of Akkermansia following exposure to adenine. Taken together, the data suggest that supplementation with leucosaccharides may effectively prevent or improve management of chronic kidney disease by restoring the microbiota and the integrity of colonic barriers.