The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception?. Issue 4 (2nd October 2017)

• Record Type: Journal Article
• Authors: Hartmann, Michaelyn A.; Sekelsky, Jeff
• Is Part Of: Fly. Volume 11:Issue 4(2017)
• Page Start: 253
• Page End: 259
• Publication Date: 2017-10-02
• Subjects: Bloom syndrome helicase -- chromosome 4 -- crossover patterning -- meiosis -- recombination; Drosophila -- Periodicals; 595.77
• DOI: 10.1080/19336934.2017.1321181
• Languages: English
• ISSNs: 1933-6934

Abstract

ABSTRACT: Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4 .