Ethnicity and diabetes complications in Sudanese population: The need for further genetic population testing. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Ahmed, Mohamed H.; Awadalla, Heitham; Osman, Mugtaba; Tahir, Hanan; Almobarak, Ahmed O.
• Is Part Of: Diabetes & metabolic syndrome. Volume 13:Issue 1(2019)
• Page Start: 430
• Page End: 433
• Publication Date: 2019-01
• Subjects: Ethnicity -- Diabetes complications -- Sudan -- Diabetes; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.10.017
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: The aim of the present study was to assess whether there is an association between ethnicity and the high prevalence of diabetes complications in Sudan. Methods: This was cross-sectional hospital-based study with 316 individuals with diabetes conducted in Khartoum state, Sudan. A questionnaire was used to collect demographic information. In addition to measurements of blood pressure, lipid profile and HbA1c, weight and height measurement were also performed for calculation of body mass index. Results: The study included individuals recruited from 62 tribes across Sudan. The effect of ethnicity on diabetic septic foot (DSF) was not statistically significant across different tribes (X-squared = 2.6098, df = 4, p-value = 0.6251). The effect of ethnicity on Albuminuria was also not statistically significant across different tribes recruited for this study (X-squared = 4.3787, df = 4, p-value = 0.3572). The Northern group carried a significantly higher unadjusted risk for development of retinopathy (OR = 1.8471, p-value = 0.04603). The Southern group was significantly different from the others regarding the effect of ethnicity on neuropathy, compared to the 'West' group (OR = 0.1905, p-value = 0.0345). The unadjusted effect for the Southern group was also significant (OR = 0.2933, p-value = 0.0320). Conclusion: There was no role of ethnicity in term of DSF and albuminuria complications. However, retinopathy likely to be seen in tribes originally from north of Sudan, while neuropathy is more likely to be found in tribes originally from the south of Sudan. Further focus genetic population testing is needed.