IL-17 production by NKG2D-expressing CD56+ T cells in type 2 diabetes. (February 2019)

• Record Type: Journal Article
• Authors: Phoksawat, Wisitsak; Jumnainsong, Amonrat; Leelayuwat, Naruemon; Leelayuwat, Chanvit
• Is Part Of: Molecular immunology. Volume 106(2019:Feb.)
• Page Start: 22
• Page End: 28
• Publication Date: 2019-02
• Subjects: T2D type 2 diabetes -- NKT cells the natural killer T cells -- NK cells the natural killer cells -- IL interleukin -- NKG2D the natural killer group 2, member D receptor -- CD cluster of differentiation -- ND non-diabetic individuals -- WC well glycemic control -- PC poor glycemic control -- N the number of samples -- PBMCs peripheral blood mononuclear cells -- HbA1c the glycated hemoglobin A1c -- NGSP the national glycohemoglobin standardization program -- IFCC the international federation of clinical chemistry and laboratory medicine -- PMA phorbol-12-myristate-13-acetate -- TCR α/β T cell receptor alpha/beta -- FBS fasting blood sugar -- TC total cholesterol -- TG triglyceride -- LDL-C low-density lipoprotein-cholesterol -- HDL-C high-density lipoprotein-cholesterol -- PBS phosphate-buffered saline -- mAbs monoclonal antibodies -- IFN-γ interferon gamma -- TNF-α tumor necrosis factor alpha -- PI3K the phosphoinositide 3-kinase -- DAP10 DNAX-activation protein 10 -- PKC-θ the protein kinase C theta -- PKC-δ the protein kinase C delta -- JAK the Janus kinase -- STAT3 the signal transducer and activator of transcription 3 -- RORγt the retinoic acid receptor-related orphan receptor gamma t -- NFAT the nuclear factor of activated T cells -- BATF the basic leucine zipper ATF-like transcription factor -- NKAP the NF kappa B activating protein -- PLZF the promyelocytic leukemia zinc finger -- NA not available; CD56+ T cells -- Type 2 diabetes -- NKG2D -- IL-17 -- HbA1c; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2018.12.008
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: High level IL-17 production of T cells expressing CD56 associated with NKG2D was identified in T2D patients. IL-17 produced by CD56+ T cells with NKG2D+ population of T2D patients was positively correlated with HbA1c level. NKG2D Hi CD56+ T cells may be potentially involved in the pathogenesis and severity of T2D. NKG2D stimulation may associate with the signaling pathway(s) of IL-17 production in CD56+ T cells. Abstract: T cells expressing CD56 (identified as CD3+CD56+) play a potential role in activation or regulation of other immune cells by secreting various cytokines. We hypothesized that these cells expressing the natural group 2, member D (NKG2D) could produce high levels of interleukin (IL)-17 in type 2 diabetes (T2D). CD56 + T cells expressing NKG2D of T2D patients, particularly in poor glycemic control (PC) predominantly produced higher IL-17 compared to the NKG2D negative population. IL-17 production of CD56 + T cells with NKG2D + was positively correlated with the level of HbA1c (N = 22, R 2 = 0.120 and P = 0.044). Interestingly, CD56+ T cells with NKG2D Hi of T2D patients had significantly higher IL-17 production than those of CD56 + T cells with NKG2D Low ( P = 0.027) and showed statistically significant with P -value < 0.001 compared to CD56 + T cells with NKG2D Hi of non-diabetic individuals (ND). In summary, CD56 + T cells expressing NKG2D, especially in the NKG2D Hi population may be involved in pathogenesis and severity of T2D via IL-17.