Dysregulated plasma glucagon levels in Japanese young adult type 1 diabetes patients. Issue 1 (7th June 2018)

• Record Type: Journal Article
• Authors: Kawamori, Dan; Katakami, Naoto; Takahara, Mitsuyoshi; Miyashita, Kazuyuki; Sakamoto, Fumie; Yasuda, Tetsuyuki; Matsuoka, Taka‐aki; Shimomura, Iichiro
• Is Part Of: Journal of diabetes investigation. Volume 10:Issue 1(2019)
• Page Start: 62
• Page End: 66
• Publication Date: 2018-06-07
• Subjects: Glucagon -- Hypoglycemia -- Type 1 diabetes; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12862
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Currently, the clinical dynamics of glucagon need to be revised based on previous data obtained from conventional glucagon radioimmunoassays. In the present study, we evaluated plasma glucagon levels in type 1 diabetes patients using a newly‐developed sandwich enzyme‐linked immunosorbent assay, and its association with clinical parameters and markers of diabetes complications were statistically assessed. The plasma glucagon level in 77 Japanese type 1 diabetes patients was 28.1 ± 17.7 pg/mL, and comparable with that reported previously for type 2 diabetes patients. However, the values were widely spread and did not correlate with plasma glucose values. Additionally, the average glucagon levels in patients in a hypoglycemic state (glucose level <80 mg/dL) did not increase (21.7 ± 12.2 pg/mL). The average glucagon level of patients experiencing hypoglycemia unawareness was significantly lower. Plasma glucagon levels evaluated using the new enzyme‐linked immunosorbent assay were dysregulated in type 1 diabetes patients in respect to plasma glucose levels, suggesting dysregulation of secretion. Abstract : Plasma glucagon levels evaluated by a new sandwich ELISA in 77 type 1 diabetes patients did not correlate with plasma glucose values suggesting dysregulation in secretion.