Three‐dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma. (17th December 2018)

• Record Type: Journal Article
• Authors: Verma, Gaurav; Chawla, Sanjeev; Mohan, Suyash; Wang, Sumei; Nasrallah, MacLean; Sheriff, Sulaiman; Desai, Arati; Brem, Steven; O'Rourke, Donald M.; Wolf, Ronald L.; Maudsley, Andrew A.; Poptani, Harish
• Is Part Of: NMR in biomedicine. Volume 32:Number 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-17
• Subjects: echo planar spectroscopic imaging -- glioblastoma -- proton MRS -- pseudoprogression -- true progression -- tumor treatment response; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4042
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : Accurate differentiation of true progression (TP) from pseudoprogression (PsP) in patients with glioblastomas (GBMs) is essential for planning adequate treatment and for estimating clinical outcome measures and future prognosis. The purpose of this study was to investigate the utility of three‐dimensional echo planar spectroscopic imaging (3D‐EPSI) in distinguishing TP from PsP in GBM patients. For this institutional review board approved and HIPAA compliant retrospective study, 27 patients with GBM demonstrating enhancing lesions within six months of completion of concurrent chemo‐radiation therapy were included. Of these, 18 were subsequently classified as TP and 9 as PsP based on histological features or follow‐up MRI studies. Parametric maps of choline/creatine (Cho/Cr) and choline/N‐acetylaspartate (Cho/NAA) were computed and co‐registered with post‐contrast T 1 ‐weighted and FLAIR images. All lesions were segmented into contrast enhancing (CER), immediate peritumoral (IPR), and distal peritumoral (DPR) regions. For each region, Cho/Cr and Cho/NAA ratios were normalized to corresponding metabolite ratios from contralateral normal parenchyma and compared between TP and PsP groups. Logistic regression analyses were performed to obtain the best model to distinguish TP from PsP. Significantly higher Cho/NAA was observed from CER (2.69 ± 1.00 versus 1.56 ± 0.51, p = 0.003), IPR (2.31 ± 0.92 versus 1.53 ± 0.56, p = 0.030), and DPR (1.80 ± 0.68 versus 1.19 ± 0.28, p = 0.035) regions in TP patients compared with those with PsP. Additionally, significantly elevated Cho/Cr (1.74 ± 0.44 versus 1.34 ± 0.26, p = 0.023) from CER was observed in TP compared with PsP. When these parameters were incorporated in multivariate regression analyses, a discriminatory model with a sensitivity of 94% and a specificity of 87% was observed in distinguishing TP from PsP. These results indicate the utility of 3D‐EPSI in differentiating TP from PsP with high sensitivity and specificity. Abstract : Significantly higher Cho/NAA was observed from contrast enhancing (CER), immediate peritumor (IPR), and distal peritumor (DPR) regions in patients with true progression (TP) compared with pseudoprogression (PsP). Significantly elevated Cho/Cr from CER was observed in TP compared with PsP. Inclusion of Cho/Cr from CER and Cho/NAA from CER, IPR, and DPR using logistic regression provided the best classification model, with a high accuracy (AUC = 0.93) along with a sensitivity of 94% and specificity of 87% in distinguishing TP from PsP.