Patient-specific in vivo right ventricle material parameter estimation for patients with tetralogy of Fallot using MRI-based models with different zero-load diastole and systole morphologies. (1st February 2019)

• Record Type: Journal Article
• Authors: Yu, Han; del Nido, Pedro J.; Geva, Tal; Yang, Chun; Tang, Alexander; Wu, Zheyang; Rathod, Rahul H.; Huang, Xueying; Billiar, Kristen L.; Tang, Dalin
• Is Part Of: International journal of cardiology. Volume 276(2019)
• Page Start: 93
• Page End: 99
• Publication Date: 2019-02-01
• Subjects: BE begin-ejection -- BF begin-filling -- BG better post-PVR outcome group -- CMR cardiac magnetic resonance -- EF ejection fraction -- EDV End-diastole volume -- EE end-ejection -- EF (EF also stands for ejection fraction. We will use full words "end-filling" if confusion arises) end-filling -- ESV End-systole volume -- FPR false positive rate -- HG Healthy human group -- LV left ventricle -- PVR pulmonary valve replacement -- ROC Receiver operating characteristic -- RV right ventricle -- RVEF RV ejection fraction -- ∆EF RV EF change -- TOF tetralogy of Fallot -- TPR true positive rate -- WG worse post-PVR outcome group -- YM Young's moduli/modulus; Tetralogy of fallot -- Pulmonary valve replacement -- Myocardium material -- Right ventricle mechanical model; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2018.09.030
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Patient-specific in vivo ventricle material parameter determination is important for cardiovascular investigations. A new cardiac magnetic image (CMR)-based modeling approach with different zero-load diastole and systole geometries was adopted to estimate right ventricle material parameter values for healthy and patients with Tetralogy of Fallot (TOF) and seeking potential clinical applications. CMR data were obtained from 6 healthy volunteers and 16 TOF patients with consent obtained. CMR-based RV/LV models were constructed using two zero-load geometries (diastole and systole, 2G model). Material parameter values for begin-filling (BF), end-filling (EF), begin-ejection (BE), and end-ejection (EE) were recorded for analyses. Effective Young's moduli (YM) for fiber direction stress-strain curves were calculated for easy comparisons. The mean EE YM value of TOF patients was 78.6% higher than that of the healthy group (HG). The mean end-ejection YM value from worse-outcome TOF group (WG) post pulmonary valve replacement (PVR) surgery was 59.5% higher than that from the better-outcome TOF group (BG). Using begin-filling YM and end-ejection YM as predictors and the classic logistic regression model to different better-outcome group patients from worse-outcome group patients, the areas under Receiver Operating Characteristic (ROC) curves were found to be 0.797 and 0.883 for begin-filling YM and end-ejection YM, respectively. The sensitivity and specificity 0.761 and 0.755 using end-ejection YM as the predictor. This preliminary study suggests that ventricle material stiffness could be a potential parameter to be used to differentiate BG patients from WG patients with further effort and large-scale patient data validations. Highlights: In vivo human ventricle material properties were quantified using MRI-based models. Tetralogy of Fallot patient ventricles were much stiffer than that from healthy. Ventricle material stiffness has large variations in a cardiac cycle.