3, 4-Dicaffeoylquinic acid protects human keratinocytes against environmental oxidative damage. (January 2019)

• Record Type: Journal Article
• Authors: Hyun, Yu Jae; Piao, Mei Jing; Kang, Kyoung Ah; Ryu, Yea Seong; Zhen, Ao Xuan; Cho, Suk Ju; Kang, Hee Kyoung; Koh, Young Sang; Ahn, Mee Jung; Kim, Tae Hoon; Hyun, Jin Won
• Is Part Of: Journal of functional foods. Volume 52(2019)
• Page Start: 430
• Page End: 441
• Publication Date: 2019-01
• Subjects: 3, 4-Dicaffeoylquinic acid -- Antioxidant -- ROS -- Human keratinocyte -- UVB -- PM2.5; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.11.026
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Exposure of UVB or PM2.5 increased intracellular ROS and induced oxidative stress in HaCaT cells. DQA protects against UVB or PM2.5 -indeced oxidative damage. In addition, it protects against UVB-induced apoptosis through inhibiting activation MAPKs. Highlights: DQA scavenged environmental UVB and PM2.5 -induced intracellular ROS. DQA treatment attenuated environmental oxidative stressed-skin cellular modifications and apoptotic cell death. FFO may be developed as a functional food against environmental oxidative stress-induced skin damage. Abstract: Skin is exposed to several harmful environmental effects including ultraviolet B (UVB) and air pollution, the most harmful component of which is particulate matter (PM). Damaging effects of UVB and PM include the generation of cellular reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, DNA damage, and apoptosis. A compound with the potential to protect the skin against environmental oxidative damage is 3, 4-dicaffeoylquinic acid (DQA), an antioxidant found in plant matter, including the coffee bean. In this study, we investigated the protective effects of DQA against UVB- and PM-induced oxidative cell damage in cultured human keratinocytes (HaCaT). We demonstrated that UVB, and PM with a diameter <2.5 µm (PM2.5 ), induced cellular damage via oxidative stress, and this was mitigated by the antioxidative action of DQA.