The mulberry-derived 1-deoxynojirimycin (DNJ) inhibits high-fat diet (HFD)-induced hypercholesteremia and modulates the gut microbiota in a gender-specific manner. (January 2019)

• Record Type: Journal Article
• Authors: Li, Yougui; Zhong, Shi; Yu, Jiaqi; Sun, Yuqing; Zhu, Jianxun; Ji, Dongfeng; Wu, Chongming
• Is Part Of: Journal of functional foods. Volume 52(2019)
• Page Start: 63
• Page End: 72
• Publication Date: 2019-01
• Subjects: 1-Deoxynojirimycin (DNJ) -- Gut microbiota -- Gender specific effect -- Hyperlipidemia -- Hypercholesteremia; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.10.034
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: 1-Deoxynojirimycin (DNJ) gender-specifically prevents HFD-induced hyperlipidemia. DNJ is more potent to prevent hypercholesteremia in female mice than in male ones. The gender disparities are not due to the serum insulin, leptin and adiponectin. DNJ is effective to modulate the gut microbiota in a gender specific manner. Abstract: 1-Deoxynojirimycin (DNJ) is an effective anti-diabetic agent with potent α-glucosidase-inhibiting activity. Here we show that DNJ exhibits gender-specific modulating effects on hypercholesteremia and gut microbiota. Oral administration of DNJ for 12 weeks significantly inhibited bodyweight gain, decreased serum cholesterol, and improved oral glucose tolerance in high-fat diet (HFD)-induced hypercholesteremic female mice but not in male mice. Microbiological analysis also revealed that DNJ showed less influence on gut microbes in male mice but markedly shifted the gut microbiota structure in female ones. DNJ significantly decreased the relative abundance of Fimicutes, which mainly attributed to the decline of the genera Allobaculum, Turicibacter, Lactobacillus, Lachnoclostridium and Roseburia, and increased Verrucomicrobia especially Akkermansia, a beneficial genus with obesity- and diabetes-alleviating effects. Together, these data revealed gender-specific anti-hypercholesteremic and gut microbiota-modulating effects of DNJ, providing a potential utility of DNJ for the treatment of hypercholesteremia.