Management of calciphylaxis in a burn center: A case series and review of the literature. Issue 1 (February 2019)

• Record Type: Journal Article
• Authors: Dado, David N.; Huang, Benjamin; Foster, Daniel V.; Nielsen, Jamison S.; Gurney, Jennifer M.; Morrow, Benjamin D.; Sharma, Kumar; Chung, Kevin K.; Ainsworth, Craig R.
• Is Part Of: Burns. Volume 45:Issue 1(2019)
• Page Start: 241
• Page End: 246
• Publication Date: 2019-02
• Subjects: Calciphylaxis -- Calficific uremic arteriolopathy; Burns and scalds -- Periodicals; 617.11
• DOI: 10.1016/j.burns.2018.09.008
• Languages: English
• ISSNs: 0305-4179

Abstract

Highlights: Calciphylaxis is a necrotizing skin disorder seen in patients with renal disease. Mortality associated with calciphylaxis is as high as 80% at one year. We report a case series of 9 patients with biopsy proven calciphylaxis. Care includes wound management, antibiotics for infection, and pain control. Burn centers are the ideal setting for calciphylaxis management. Abstract: Calciphylaxis is a rare, necrotizing skin disorder usually associated with kidney disease, but also caused by many other systemic illnesses. This disease is associated with mortality rates as high as 80% at 1 year. We present the demographic and clinical data of nine patients with calciphylaxis treated at our burn center over a 10 year period. We review the literature on the clinical presentation, pathophysiology, diagnosis and treatment of this rare disease. We propose that these patients be treated similar to patients with thermal burn injury; meaning intensive wound care, surgical management, critical care and physical therapy. Burn centers are uniquely capable of caring for these incredibly complex patients due to their experience in managing patients with extensive skin and soft tissue defects, wounds and diseases.