Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats. (January 2019)

• Record Type: Journal Article
• Authors: Lin, Kuan-Ho; Shibu, Marthandam Asokan; Peramaiyan, Rajendran; Chen, Ya-Fang; Shen, Chia-Yao; Hsieh, You-Liang; Chen, Ray-Jade; Viswanadha, Vijaya Padma; Kuo, Wei-Wen; Huang, Chih-Yang
• Is Part Of: Journal of functional foods. Volume 52(2019)
• Page Start: 212
• Page End: 218
• Publication Date: 2019-01
• Subjects: Hypertension -- 3, 3′, 4′, 7-Tetrahydroxyflavone -- Fisetin -- Flavonoid -- Cardiac remodeling; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.10.038
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Fisetin reduces Calcinurin-NFATC3-GATA4 associated cellular hypertrophy and restores cardiac function and cardiac architecture. Highlights: Fisetin is a naturally occurring flavonoid in fruits and vegetables. Effect of fisetin on cardiac hypertrophy in hypertensive SHRs was investigated. Fisetin reduced Calcinurin-NFATC3-GATA4 associated cellular hypertrophy. Fisetin potentially restores cardiac function and cardiac architecture. Abstract: Fisetin, a naturally occurring flavonoid in fruits, nuts and vegetables possess antioxidant and anti-inflammatory properties. This study shows that fisetin exerts preventive and therapeutic effects on hypertension associated cardiac abnormalities in H9c2 cells and Spontaneously Hypertensive Rats (SHRs). For In vitro analysis, H9c2 cells were challenged with AngII and Fisetin (50 µM/mL) was administered either before 2 h or after 12 h of AngII challenge. For In vivo studies, SHRs received oral fisetin (10 mg/kg, twice a week for 6 weeks) and their cardiac function was analyzed by echocardiography. Histological studies and Western blotting were performed to assess the severity and the mechanism of the underlying cardiac abnormality. Fisetin effectively suppressed calcineurin-NFATC3 involved cellular hypertrophic effects as observed in H9c2 cells and in SHR hearts. Fisetin also enhanced cardiac function and restored cardiac morphology and therefore, fisetin is a potential agent against hypertension associated hypertrophy and cardiac deterioration.