Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities. (16th October 2018)

• Record Type: Journal Article
• Authors: Keizer, Ron J.; ter Heine, Rob; Frymoyer, Adam; Lesko, Lawrence J.; Mangat, Ranvir; Goswami, Srijib
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 7:Number 12(2018)
• Page Start: 785
• Page End: 787
• Publication Date: 2018-10-16
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12353
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.