Data Mining of Small RNA-Seq Suggests an Association Between Prostate Cancer and Altered Abundance of 5′ Transfer RNA Halves in Seminal Fluid and Prostatic Tissues. Issue 10 (19th February 2018)

• Record Type: Journal Article
• Authors: Dhahbi, Joseph M; Atamna, Hani; Selth, Luke A
• Is Part Of: Biomarkers in cancer. Volume 2018:Issue 10(2018)
• Publication Date: 2018-02-19
• Subjects: Extracellular 5′ tRNA halves -- prostate cancer biomarkers -- seminal fluid; Tumor markers -- Periodicals; Cancer -- Periodicals; Biochemical markers -- Periodicals; 616.99405
• DOI: 10.1177/1179299X18759545
• Languages: English
• ISSNs: 1179-299X

Abstract

Extracellular RNAs are gaining clinical interest as biofluid-based noninvasive markers for diseases, especially cancer. In particular, derivatives of transfer RNA (tRNA) are emerging as a new class of small-noncoding RNAs with high biomarker potential. We and others previously reported alterations in serum levels of specific tRNA halves in disease states including cancer. Here, we explored seminal fluid for tRNA halves as potential markers of prostate cancer. We found that 5′ tRNA halves are abundant in seminal fluid and are elevated in prostate cancer relative to noncancer patients. Importantly, most of these tRNA halves are also detectable in prostatic tissues, and a subset were increased in malignant relative to adjacent normal tissue. These findings emphasize the potential of 5′ tRNA halves as noninvasive markers for prostate cancer screening and diagnosis and provide leads for future work to elucidate a putative role of the 5′ tRNA halves in carcinogenesis.