Biomarkers for bipolar disorder: current status and challenges ahead. (2nd January 2019)

• Record Type: Journal Article
• Authors: Teixeira, Antonio L.; Colpo, Gabriela D.; Fries, Gabriel R.; Bauer, Isabelle E.; Selvaraj, Sudhakar
• Is Part Of: Expert review of neurotherapeutics. Volume 19:Number 1(2019)
• Page Start: 67
• Page End: 81
• Publication Date: 2019-01-02
• Subjects: Bipolar disorder -- biomarkers -- neuroimaging -- inflammation markers -- oxidative stress markers -- personalized psychiatry -- neurophysiological markers -- genetics; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1080/14737175.2019.1550361
• Languages: English
• ISSNs: 1473-7175

Abstract

ABSTRACT: Introduction : Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered : This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary : There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.