Chiral Isocamphoric Acid: Founding a Large Family of Homochiral Porous Materials. (17th May 2018)

• Record Type: Journal Article
• Authors: Zhao, Xiang; Nguyen, Edward T.; Hong, Anh N.; Feng, Pingyun; Bu, Xianhui
• Is Part Of: Angewandte Chemie. Volume 130:Number 24(2018)
• Page Start: 7219
• Page End: 7223
• Publication Date: 2018-05-17
• Subjects: Camphersäure -- Chirale Liganden -- Homochirale poröse Materialien -- Isocamphersäure -- Metall-organische Gerüststrukturen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201802911
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Homochiral metal–organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low‐cost, racemization‐resistant, and versatile enantiopure building blocks. Among chiral building blocks, d ‐camphoric acid is highly prolific, yet, its trans ‐isomer, l ‐isocamphoric acid, has remained unknown in the entire field of solid‐state materials. Its rich yet totally untapped synthetic and structural chemistry has now been investigated through the synthesis of a large family of homochiral metal isocamphorates. The first observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials.