Synchrotron radiation imaging is a powerful tool to image brain microvasculature. Issue 3 (24th February 2014)

• Record Type: Journal Article
• Authors: Zhang, Mengqi; Peng, Guanyun; Sun, Danni; Xie, Yuanyuan; Xia, Jian; Long, Hongyu; Hu, Kai; Xiao, Bo
• Is Part Of: Medical physics. Volume 41:Issue 3(2014)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-02-24
• Subjects: Angiography -- Biomedical imaging -- Neuroscience; brain -- cardiovascular system -- neurophysiology -- reviews -- synchrotron radiation; synchrotron radiation -- microangiography -- phase‐contrast imaging -- microvasculature -- brain; Biological material, e.g. blood, urine; Haemocytometers; Medical imaging -- Medical X‐ray imaging -- Brain -- Vascular system -- X‐ray imaging -- Medical image contrast -- Image sensors -- Angiography -- Tissues -- X‐rays; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4865784
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Synchrotron radiation (SR) imaging is a powerful experimental tool for micrometer‐scale imaging of microcirculation in vivo . This review discusses recent methodological advances and findings from morphological investigations of cerebral vascular networks during several neurovascular pathologies. In particular, it describes recent developments in SR microangiography for real‐time assessment of the brain microvasculature under various pathological conditions in small animal models. It also covers studies that employed SR‐based phase‐contrast imaging to acquire 3D brain images and provide detailed maps of brain vasculature. In addition, a brief introduction of SR technology and current limitations of SR sources are described in this review. In the near future, SR imaging could transform into a common and informative imaging modality to resolve subtle details of cerebrovascular function.