Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study: 妊娠期间的血脂浓度与妊娠糖尿病风险:一项纵向研究. Issue 6 (29th September 2017)

• Record Type: Journal Article
• Authors: Bao, Wei; Dar, Sharon; Zhu, Yeyi; Wu, Jing; Rawal, Shristi; Li, Shanshan; Weir, Natalie L.; Tsai, Michael Y.; Zhang, Cuilin
• Other Names: Liu Simin guestEditor.; Sun Qi guestEditor.
• Is Part Of: Journal of diabetes. Volume 10:Issue 6(2018)
• Page Start: 487
• Page End: 495
• Publication Date: 2017-09-29
• Subjects: cholesterol -- gestational diabetes -- lipids -- pregnancy -- triglycerides; 胆固醇 -- 妊娠糖尿病 -- 血脂 -- 妊娠 -- 三酰甘油; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12563
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM. Methods: This study was a nested case‐control study including 107 GDM cases and 214 matched non‐GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high‐density lipoprotein cholesterol (HDL‐C) were measured by enzymatic assays. Low‐density lipoprotein cholesterol (LDL‐C) was calculated using Friedewald's formula. Results: Plasma triglycerides, total cholesterol, and LDL‐C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P trend = 0.045) for HDL‐C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P trend = 0.005) for HDL‐C. No significant associations were observed for total cholesterol and LDL‐C concentrations with risk of GDM. Conclusions: Higher plasma triglyceride and lower HDL‐C concentrations in early and mid‐pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL‐C concentrations during pregnancy were not significantly associated with GDM risk. Abstract : Highlights Higher concentrations of triglycerides and lower concentrations of high‐density lipoprotein cholesterol in early and mid‐pregnancy are significantly related to a greater risk of gestational diabetes mellitus (GDM). Total cholesterol and low‐density lipoprotein cholesterol concentrations during pregnancy were not associated with risk of GDM. This study is based on longitudinal assessments of plasma lipid concentrations across pregnancy in a multiracial/multi‐ethnic pregnancy cohort, which is uniquely suited to address temporal associations of plasma lipids in early and mid‐pregnancy with the development of subsequent GDM.