Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis. Issue 1 (21st November 2016)

• Record Type: Journal Article
• Authors: Fernández‐Carballido, Cristina; Navarro‐Compán, Victoria; Castillo‐Gallego, Concepción; Castro‐Villegas, Maria C.; Collantes‐Estévez, Eduardo; de Miguel, Eugenio
• Other Names: Collantes E. investigator.; Reina Sofía H. investigator.; Carmona L. investigator.; Gobbo M. investigator.; Mulero J. investigator.; Puerta de Hierro H. investigator.; Muñoz‐Fernández S. investigator.; Infanta Sofía H. investigator.; Zarco P. investigator.; Alcorcón F. H. investigator.; Rivera J. investigator.; Gregorio Marañón H. investigator.; López Robledillo J. C. investigator.; Niño Jesús H. investigator.; Castillo Gallego C. investigator.; La Paz H. U. investigator.; Rosas J. investigator.; Santos G. investigator.; Marina Baixa H. investigator.; Fernández Sueiro J. L. investigator.; Pinto Tasende J. investigator.; González Díaz de Rabago E. investigator.; Juanv H. U. investigator.; Montilla C. investigator.; Gómez Castro López S. investigator.; del Pino Montes R. J. investigator.; de Salamanca H. U. investigator.; Granados Bautista I. P. investigator.; Hernández Sanz A. investigator.; Virgen de la Salud H. investigator.; Sanz Sanz J. investigator.; Puerta de Hierro H. investigator.; Fernández Prada M. investigator.; Tornero J. investigator.; de Guadalajara H. U. investigator.; Campos C. investigator.; Calvo J. investigator.; de Valencia H. G. U. investigator.; Juanola X. investigator.; Ríos V. investigator.; de Bellvitge H. U. investigator.; Moreno E. investigator.; Rotés M. I. investigator.; de San Rafael H. investigator.; Ibero I. investigator.; Jovaní V. investigator.; Martínez Alberola N. investigator.; de Elda H. G. U. investigator.; Linares L. F. investigator.; Moreno Ramos M. J. investigator.; Uceda A. investigator.; Moreno Martínez M. J. investigator.; Beteta M. D. investigator.; Virgen de la Arrixaca H. U. investigator.; Quevedo J. C. investigator.; Rodríguez Lozano C. investigator.; Negrín H. U. investigator.; Trujillo E. investigator.; Bustabad S. investigator.; de Canarias H. U. investigator.; Román Ivorra J. A. investigator.; Muñoz Gil S. investigator.; Peset H. U. investigator.; Juan Mas A. investigator.; Ros Vilamajó I. investigator.; Ibáñez Barceló M. investigator.; Son Llatzer H. investigator.; Gratacós Matmija J. investigator.; Moreno Martínez‐Loza M. investigator.; Sabadell H. investigator.; Almodóvar R. investigator.; Fundación Alcorcón H. investigator.; Rejón E. investigator.; Rodríguez Montero S. investigator.; Virgen de Valme H. U. investigator.; Ruiz Jimeno T. investigator.; Sierrallana H. investigator.; Aznar J. J. investigator.; Chamizo Carmona E. investigator.; Garrido Puñal N. investigator.; de Mérida H. investigator.; Fernández Dapica P. investigator.; Brito Brito E. investigator.; Ramón y Cajal H. investigator.; Pérez Pampín E. investigator.; Clínico H. investigator.;
• Is Part Of: Arthritis care & research. Volume 69:Issue 1(2017:Jan.)
• Page Start: 150
• Page End: 155
• Publication Date: 2016-11-21
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.22908
• Languages: English
• ISSNs: 2151-464X

Abstract

Abstract : Objective: To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. Methods: This was a cross‐sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility. Results: In total, 259 patients were included. The mean ± SD age was 32.2 ± 6.9 years, disease duration was 13.3 ± 6.8 months, Ankylosing Spondylitis Quality of Life score was 5.9 ± 4.8, Bath Ankylosing Spondylitis Functional Index score was 2.4 ± 2.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4 ± 1.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8 ± 2.3, C‐reactive protein (CRP) level was 9.7 ± 13.2 mg/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI‐s) score was 1.7 ± 1.6. HRQOL was mainly associated with disease activity on univariate analysis (β values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; P < 0.01 for all), whereas the association with radiographic damage was weaker (standardized β for BASRI‐s 0.142; P < 0.05). On multivariate models, HRQOL only remained significantly associated with disease activity (standardized β for BASDAI 0.330; P < 0.01, and physician VAS 0.205 and night back pain VAS 0.210; P = 0.01). Similarly, physical function was associated with disease activity and radiographic damage on univariate analysis, but only with disease activity (BASDAI β 0.466; P < 0.01) on multivariate analysis. However, spinal mobility was associated with radiographic damage in both univariate and multivariate analyses. Conclusion: Patients with axial SpA already have impaired quality of life and physical function, albeit mildly, at the beginning of their disease course. Both outcomes are mainly associated with disease activity in these patients.