A Readily Accessible Class of Chiral Cp Ligands and their Application in RuII‐Catalyzed Enantioselective Syntheses of Dihydrobenzoindoles. (6th April 2018)

• Record Type: Journal Article
• Authors: Wang, Shou‐Guo; Park, Sung Hwan; Cramer, Nicolai
• Is Part Of: Angewandte Chemie. Volume 130:Number 19(2018)
• Page Start: 5557
• Page End: 5560
• Publication Date: 2018-04-06
• Subjects: Asymmetrische Katalyse -- Cyclopentadienylliganden -- Cyclisierungen -- Ligandenentwicklung -- Ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201802244
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Chiral cyclopentadienyl (Cp x ) ligands have a large application potential in enantioselective transition‐metal catalysis. However, the development of concise and practical routes to such ligands remains in its infancy. We present a convenient and efficient two‐step synthesis of a novel class of chiral Cp x ligands with tunable steric properties that can be readily used for complexation, giving Cp x Rh I, Cp x Ir I, and Cp x Ru II complexes. The potential of this ligand class is demonstrated with the latter in the enantioselective cyclization of azabenzonorbornadienes with alkynes, affording dihydrobenzoindoles in up to 98:2 e.r., significantly outperforming existing binaphthyl‐derived Cp x ligands.