Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans. Issue 1 (14th October 2014)

• Record Type: Journal Article
• Authors: Björkhem-Bergman, Linda; Johansson, Maria; Morgenstern, Ralf; Rane, Anders; Ekström, Lena
• Is Part Of: FEBS open bio. Volume 4:Issue 1(2014)
• Page Start: 886
• Page End: 891
• Publication Date: 2014-10-14
• Subjects: Thioredoxin reductase 1 -- Microsomal glutathione transferase 1 -- Fetus -- Liver -- Splice variants -- DNA methylation; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.fob.2014.10.005
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : In conclusion, the expression of TXNRD1 is higher in fetuses than in adults and might be of importance during fetal life. Hepatic TXNRD1 and MGST1 are co‐expressed in both fetuses and adults suggesting common regulatory mechanisms. Abstract : The expression of the enzymes TRXR1 and MGST1 during fetal life are investigated for the first time. The expression of TXRX1 is 7 times higher in fetuses than in adults. The expression of MGST1 is higher in adults than in fetuses. Hepatic TRXR1 and MGST 1 are co‐expressed, suggesting common regulatory mechanisms. The effect of the demethylating agent 5‐AZA on TRXR1 expression is reported.