Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation. Issue 1 (20th June 2016)

• Record Type: Journal Article
• Authors: Argüello, Rafael J.; Reverendo, Marisa; Gatti, Evelina; Pierre, Philippe
• Is Part Of: Immunological reviews. Volume 272:Issue 1(2016)
• Page Start: 28
• Page End: 38
• Publication Date: 2016-06-20
• Subjects: DRiPs -- antigenic peptide -- peptidome -- DALIS -- autophagy -- ribosome; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12427
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: Antigenic peptides presented in the context of major histocompatibility complex (MHC) molecules originate from the degradation of both self and non‐self proteins. T cells can therefore recognize at the surface of surveyed cells, the self‐peptidome produced by the cell itself (mostly inducing tolerance) or immunogenic peptides derived from exogenous origins. The initiation of adaptive immune responses by dendritic cells (DCs), through the antigenic priming of naïve T cells, is associated to microbial pattern recognition receptors engagement. Activation of DCs by microbial product or inflammatory cytokines initiates multiple processes that maximize DC capacity to present exogenous antigens and stimulate T cells by affecting major metabolic and membrane traffic pathways. These include the modulation of protein synthesis, the regulation of MHC and co‐stimulatory molecules transport, as well as the regulation of autophagy, that, all together promote exogenous antigen presentation while limiting the display of self‐antigens by MHC molecules.