Cover Picture: BODIPY‐Based Nanomicelles as Near‐Infrared Fluorescent "Turn‐On" Sensors for Biogenic Thiols (ChemNanoMat 5/2016). Issue 5 (3rd May 2016)

• Record Type: Journal Article
• Authors: Huang, Ling; Duan, Ran; Li, Zhanjun; Zhang, Yuanwei; Zhao, Jianzhang; Han, Gang
• Is Part Of: ChemNanoMat. Volume 2:Issue 5(2016)
• Page Start: 315
• Page End: 315
• Publication Date: 2016-05-03
• Subjects: BODIPY -- fluorescence -- nanomicelles -- sensors -- thiols; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201600084
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract : Novel, aqueous‐soluble, near‐infrared (NIR) organic‐dye‐containing nanomicelles were developed as biogenic thiol sensors. Near‐infrared‐emitting distyryl‐BODIPY was chemically linked to the fluorescence quencher group of 2, 4‐dinitrobenzenesulfonyl (DNBS) and then was water solubilized and formed into nanomicelles via polylactic acid–polyethylene glycol (PLA‐PEG) encapsulation. When thiols react with the DNBS moiety, subsequent recovery of distyryl‐BODIPY fluorescence was observed both in vitro and in living cells. These nanomicelles possess excellent photostability, are selective towards biogenic thiols, and function within a quite broad pH range (pH=3–10). This work provides a convenient and general method to construct intracellular nanoprobes for biogenic thiols and should also pave the way to numerous other fluorescence‐dye‐based sensor designs. More information can be found in the Communication by G. Han et al. onpage 396 in Issue 5, 2016 (DOI:10.1002/cnma.201600019 ).