Association of L‐FABP T94A and MTP I128T Polymorphisms with Hyperlipidemia in Chinese Subjects. Issue 3 (7th February 2015)

• Record Type: Journal Article
• Authors: Tian, Yingying; Li, Hui; Wang, Shanbo; Yan, Jin; Chen, Zhiheng; Li, Zhenyu; Feng, Han; Zhou, Honghao; Ouyang, Dongsheng
• Is Part Of: Lipids. Volume 50:Issue 3(2015)
• Page Start: 275
• Page End: 282
• Publication Date: 2015-02-07
• Subjects: L‐FABP -- MTP -- Polymorphism -- Hyperlipidemia; Lipids -- Periodicals; Lipids -- Periodicals; Lipiden; Lipides -- Périodiques; 547.77
• DOI: 10.1007/s11745-015-3990-3
• Languages: English
• ISSNs: 0024-4201

Abstract

Abstract: The purpose of this study was to evaluate the relation between the L‐FABP T94A and MTP I128T polymorphisms and hyperlipidemia in Chinese subjects. We recruited 390 volunteers: 201 hyperlipidemic and 189 healthy volunteers. The L‐FABP T94A and MTP I128T polymorphisms were genotyped using polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP). Anthropometry, lipid profile, and liver function of the subjects were determined. We observed that male carriers of the L‐FABP A94 allele had significantly higher body weight ( P = 0.012), higher body mass index (BMI) ( P = 0.014), and higher plasma triacylglycerol levels (TAG) ( P = 0.033) and lower ratios of high‐density lipoprotein cholesterol (HDL‐C) to total cholesterol (TC) ( P = 0.008) than T94 homozygotes. The MTP T128 allele was associated with significantly lower serum TC ( P < 0.001) and low‐density lipoprotein cholesterol (LDL‐C) ( P < 0.001) levels in males. There was a direct correlation between the MTP T128 allele and a decreased risk of hyperlipidemia after adjusting for body mass index (OR = 0.327, 95 % CI: 0.178–0.600, P < 0.001). In conclusion, both the MTP I128T and the L‐FABP T94A polymorphisms can affect serum lipid levels in the Chinese population. The MTP T128 allele offers protection against hyperlipidemia in the Chinese population.