Towards integration of PET/MR hybrid imaging into radiation therapy treatment planning. Issue 7 (12th June 2014)

• Record Type: Journal Article
• Authors: Paulus, Daniel H.; Thorwath, Daniela; Schmidt, Holger; Quick, Harald H.
• Is Part Of: Medical physics. Volume 41:Issue 7(2014)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-06-12
• Subjects: Positron emission tomography (PET) -- Magnetic resonance imaging -- Therapeutic applications, including brachytherapy -- Image quality -- Computed tomography; biomedical equipment -- biomedical MRI -- coils -- medical image processing -- phantoms -- positron emission tomography -- radiation therapy; PET/MR hybrid imaging -- RT treatment planning -- RT table overlay -- RF coil holders -- PET attenuation correction -- PET quantification; Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging -- Radiation therapy -- Biological material, e.g. blood, urine; Haemocytometers -- Digital computing or data processing equipment or methods, specially adapted for specific applications -- Image data processing or generation, in general -- Coils -- Coils; Windings; Conductive connections -- Scintigraphy -- Measuring half‐life of a radioactive substance; Positron emission tomography -- Medical magnetic resonance imaging -- Computed tomography -- Medical treatment planning -- Medical image noise -- Photons -- Magnetic resonance -- Coils; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4881317
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Purpose: Multimodality imaging has become an important adjunct of state‐of‐the‐art radiation therapy (RT) treatment planning. Recently, simultaneous PET/MR hybrid imaging has become clinically available and may also contribute to target volume delineation and biological individualization in RT planning. For integration of PET/MR hybrid imaging into RT treatment planning, compatible dedicated RT devices are required for accurate patient positioning. In this study, prototype RT positioning devices intended for PET/MR hybrid imaging are introduced and tested toward PET/MR compatibility and image quality. Methods: A prototype flat RT table overlay and two radiofrequency (RF) coil holders that each fix one flexible body matrix RF coil for RT head/neck imaging have been evaluated within this study. MR image quality with the RT head setup was compared to the actual PET/MR setup with a dedicated head RF coil. PET photon attenuation and CT‐based attenuation correction (AC) of the hardware components has been quantitatively evaluated by phantom scans. Clinical application of the new RT setup in PET/MR imaging was evaluated in an in vivo study. Results: The RT table overlay and RF coil holders are fully PET/MR compatible. MR phantom and volunteer imaging with the RT head setup revealed high image quality, comparable to images acquired with the dedicated PET/MR head RF coil, albeit with 25% reduced SNR. Repositioning accuracy of the RF coil holders was below 1 mm. PET photon attenuation of the RT table overlay was calculated to be 3.8% and 13.8% for the RF coil holders. With CT‐based AC of the devices, the underestimation error was reduced to 0.6% and 0.8%, respectively. Comparable results were found within the patient study. Conclusions: The newly designed RT devices for hybrid PET/MR imaging are PET and MR compatible. The mechanically rigid design and the reproducible positioning allow for straightforward CT‐based AC. The systematic evaluation within this study provides the technical basis for the clinical integration of PET/MR hybrid imaging into RT treatment planning.