Gastrointestinal disorders in joint hypermobility syndrome/Ehlers‐Danlos syndrome hypermobility type: A review for the gastroenterologist. Issue 8 (13th January 2017)

• Record Type: Journal Article
• Authors: Beckers, A. B.; Keszthelyi, D.; Fikree, A.; Vork, L.; Masclee, A.; Farmer, A. D.; Aziz, Q.
• Is Part Of: Neurogastroenterology & motility. Volume 29:Issue 8(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-13
• Subjects: Ehlers‐Danlos syndrome -- functional dyspepsia -- functional GI disorders -- joint hypermobility syndrome; Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.13013
• Languages: English
• ISSNs: 1350-1925

Abstract

Abstract: Background: Joint hypermobility syndrome (JHS)/Ehlers‐Danlos syndrome hypermobility type (EDS‐HT) is the most common hereditary non‐inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal (GI) symptoms. Furthermore, JHS/EDS‐HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome. Purpose: The aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS/EDS‐HT. In addition, we consider the clinical implications of the diagnosis and treatment of JHS/EDS‐HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders. Abstract : In this review article, we examine the nature of gastrointestinal symptoms and their underlying pathophysiology in JHS/EDS‐HT and consider the clinical implications of the diagnosis and treatment of this syndrome for practicing clinicians in gastroenterology.