2‐Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis. (14th April 2018)

• Record Type: Journal Article
• Authors: Guerrero‐Corella, Andrea; Esteban, Francisco; Iniesta, Manuel; Martín‐Somer, Ana; Parra, Mario; Díaz‐Tendero, Sergio; Fraile, Alberto; Alemán, Jose
• Is Part Of: Angewandte Chemie. Volume 130:Number 19(2018)
• Page Start: 5448
• Page End: 5452
• Publication Date: 2018-04-14
• Subjects: Aminosäuren -- Chemische Auxiliare -- Difunktionelle Katalyse -- Organokatalyse -- Wasserstoffbrückenaktivierung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201800435
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of α, γ‐diamino acid derivatives with excellent stereoselectivity.