Asymmetric Hydroxylation of 4‐Substituted Pyrazolones Catalyzed by Natural Cinchona Alkaloids. Issue 24 (29th November 2016)

• Record Type: Journal Article
• Authors: Xue, Fuzhao; Bao, Xiaoze; Zou, Liwei; Qu, Jingping; Wang, Baomin
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 24(2016)
• Page Start: 3971
• Page End: 3976
• Publication Date: 2016-11-29
• Subjects: asymmetric catalysis -- Cinchona alkaloids -- hydroxylation -- pyrazolones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201601070
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A natural quinine‐catalyzed, efficient and practical asymmetric α‐hydroxylation of 4‐substituted pyrazolones has been developed, delivering a broad spectrum of pyrazolones bearing an oxygen‐attached carbon stereocenter at C‐4 in high yields and excellent enantioselectivities. The broad substrate scope, ready availability of the catalyst, ease of operation, and valuable transformation of the product highlight the practical utility of this process. Abstract :