Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules. (15th February 2017)

• Record Type: Journal Article
• Authors: Crowley, Shauna M.; Vallance, Bruce A.; Knodler, Leigh A.
• Is Part Of: Cellular microbiology. Volume 19:Number 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-15
• Subjects: bacterial infections -- caspase‐11 -- caspase‐4 -- intestinal epithelial cells -- macrophages -- pathogenesis; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.12730
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: Although much research has focused on defining the actions of caspase‐1 containing canonical inflammasomes in promoting host defense, noncanonical inflammasomes have received comparatively little attention. Exciting new concepts have recently emerged detailing their atypical mechanism of activation, importance in defending against cytosolic Gram‐negative pathogens, and role in innate immune defenses of nonmyeloid cells, which has revamped interest in the study of noncanonical inflammmasomes. Here, we will discuss these latest findings about caspase‐4, ‐5, and ‐11 containing inflammasomes in the context of their role in pathogen elimination in mice and humans.