Direct Access to Aryl Bis(trifluoromethyl)carbinols from Aryl Bromides or Fluorosulfates: Palladium‐Catalyzed Carbonylation. (14th May 2018)

• Record Type: Journal Article
• Authors: Domino, Katrine; Veryser, Cedrick; Wahlqvist, Benjamin A.; Gaardbo, Cecilie; Neumann, Karoline T.; Daasbjerg, Kim; De Borggraeve, Wim M.; Skrydstrup, Troels
• Is Part Of: Angewandte Chemie. Volume 130:Number 23(2018)
• Page Start: 6974
• Page End: 6978
• Publication Date: 2018-05-14
• Subjects: Arylhalogenide -- Carbonylierungen -- Fluor -- Isotopenmarkierung -- Palladium; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201802647
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A palladium‐catalyzed carbonylative approach for the direct conversion of (hetero)aryl bromides into their α, α‐bis(trifluoromethyl)carbinols is described, and it employs only stoichiometric amounts of carbon monoxide and trifluoromethyltrimethylsilane. In addition, aryl fluorosulfates proved highly compatible with these reaction conditions. The method is tolerant of a diverse set of functional groups, and it is adaptable to late‐stage carbon‐isotope labeling.