Sex and age discrepancy of HbA1c and fetal hemoglobin determined by HPLC in a large Chinese Han population: 利用HPLC法测定大样本量中国汉族人群糖化血红蛋白与胎儿血红蛋白的性别和年龄差异. Issue 6 (14th May 2017)

• Record Type: Journal Article
• Authors: Hu, Jihong; Gao, Jun; Li, Jianbo
• Other Names: Liu Simin guestEditor.; Sun Qi guestEditor.
• Is Part Of: Journal of diabetes. Volume 10:Issue 6(2018)
• Page Start: 458
• Page End: 466
• Publication Date: 2017-05-14
• Subjects: age -- fetal hemoglobin -- hemoglobin A1c -- High Performance Liquid Chromatography -- sex; 年龄 -- 胎儿血红蛋白 -- HbA1c -- 高效液相色谱法 -- 性别; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12544
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: It is accepted that HbA1c is an effective indicator to evaluate glycemic control. Fetal hemoglobin (HbF) is seldom measured because traditional detection is inconvenient. In this regard, there may be an advantage in using HPLC autoanalysis of HbA1c as a surrogate method for HbF detection. The aim of the present study was to explore the distribution of HbA1c and HbF in a large Chinese Han population. Methods: In all, 70 553 blood samples were collected between January 2012 and June 2016. Study subjects were inpatients undergoing routine medical care and were divided into four groups based on age: Group A, 20–39 years; Group B, 40–59 years; Group C, 60–79 years; and Group D, ≥80 years. Blood HbA1c and HbF concentrations were measured by HPLC using a Tosho Bioscience (Tokyo, Japan) G8 analyzer. Results: There was a positive association between HbA1c and age, and a negative association between HbF and age. The concentration range of HbF was narrow and HbF concentrations were significantly higher in females than males, regardless of age (median 0.7% vs 0.6%, respectively; P < 0.0001). There was a low degree of correlation between HbF and HbA1c ( r = 0.181, P < 0.0001). Although median HbA1c levels were higher in male than female subjects aged 20–59 years (5.5% vs 5.4%, respectively, in Group A; 5.9% vs 5.8%, respectively in Group B), in the 60–79 years group, HbA1c levels were lower in males than females (6.1% vs 6.2%, respectively; P < 0.0001). Conclusions: The data suggest that sex and age should be considered in clinical interpretation of HbA1c. Abstract : Highlights The present study found that HbA1c was positively associated with age, whereas fetal hemoglobin (HbF) was negatively associated with age. Male subjects had higher HbA1c levels in the 20–59 years age group and lower HbA1c levels in the 60–79 years age group compared with females. Sex and age should be considered in the clinical interpretation of HbA1c values.