Asymmetric P−C Bond Formation: Diastereoselective Synthesis of Adjacent P, C‐Stereogenic Allylic Phosphorus Compounds. Issue 9 (29th March 2016)

• Record Type: Journal Article
• Authors: Xie, Peizhong; Guo, Lei; Xu, Lanlan; Loh, Teck‐Peng
• Is Part Of: Chemistry, an Asian journal. Volume 11:Issue 9(2016)
• Page Start: 1353
• Page End: 1356
• Publication Date: 2016-03-29
• Subjects: 1, 3-bisphosphinylpropanes -- kinetic resolution -- organocatalysis -- P−C bond formation -- P-stereogenic compounds; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201600108
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A novel catalytic asymmetric P−C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P, C‐stereogenic phosphorus compounds in high yields with high regio‐ and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched ( S P )‐phosphinates through kinetic resolution. Abstract : New strategy for adjacent P, C‐stereogenic phosphorus compounds : A novel catalytic asymmetric P−C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P, C‐stereogenic phosphorus compounds in high yields with high regio‐ and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched ( S P )‐phosphinates through kinetic resolution.