H2‐Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration. (15th March 2016)

• Record Type: Journal Article
• Authors: Gutiérrez‐Sanz, Óscar; Natale, Paolo; Márquez, Ileana; Marques, Marta C.; Zacarias, Sonia; Pita, Marcos; Pereira, Inês A. C.; López‐Montero, Iván; De Lacey, Antonio L.; Vélez, Marisela
• Is Part Of: Angewandte Chemie. Volume 128:Number 21(2016)
• Page Start: 6324
• Page End: 6328
• Publication Date: 2016-03-15
• Subjects: Bioelektrochemie -- Biophysik -- Immobilisierung -- Membranproteine -- Protonentransport; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201600752
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F1 F0 ‐ATPase in a lipid membrane can couple the electrochemical oxidation of H2 to the synthesis of ATP. This electrode‐assisted conversion of H2 gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products.