Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm. Issue 1 (21st April 2014)

• Record Type: Journal Article
• Authors: Guo, Lili; Volle, Deanna J.; Lewis, Robert E.
• Is Part Of: FEBS open bio. Volume 4:Issue 1(2014)
• Page Start: 420
• Page End: 425
• Publication Date: 2014-04-21
• Subjects: KSR2 -- Scaffold -- Sperm; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.fob.2014.04.004
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal‐regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk‐1 ( Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2 −/− mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T‐KSR2). Further analysis demonstrates T‐KSR2 is specific to mouse testes and mature sperm cells. The detection of T‐KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility. Abstract : A truncated kinase suppressor of Ras 2 (T‐KSR2) mRNA was identified. T‐KSR2 is expressed exclusively in mouse testes and sperm. Analysis of T‐KSR2 may enhance understanding of spermatogenesis and fertility.