Relationship between dietary carbohydrates intake and circulating sex hormone‐binding globulin levels in postmenopausal women: 在绝经后妇女中膳食碳水化合物摄入量与血液循环中性激素结合球蛋白水平的关系. Issue 6 (14th May 2017)

• Record Type: Journal Article
• Authors: Huang, Mengna; Liu, Jinjie; Lin, Xiaochen; Goto, Atsushi; Song, Yiqing; Tinker, Lesley F.; Chan, Kei‐hang Katie; Liu, Simin
• Other Names: Liu Simin guestEditor.; Sun Qi guestEditor.
• Is Part Of: Journal of diabetes. Volume 10:Issue 6(2018)
• Page Start: 467
• Page End: 477
• Publication Date: 2017-05-14
• Subjects: dietary carbohydrates -- glycemic index -- glycemic load -- sex hormone binding globulin (SHBG) -- type 2 diabetes; 膳食碳水化合物 -- 血糖指数 -- 血糖负荷 -- 性激素结合球蛋白 -- 2型糖尿病; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12550
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: Low circulating levels of sex hormone‐binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone‐dependent cancers, although the relationship between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. Methods: Among postmenopausal women with available SHBG measurements at baseline ( n = 11 159) in the Women's Health Initiative, a comprehensive assessment was conducted of total dietary carbohydrates, glycemic load (GL), glycemic index (GI), fiber, sugar, and various carbohydrate‐abundant foods in relation to circulating SHBG levels using multiple linear regressions adjusting for potential covariates. Linear trend was tested across quartiles of dietary variables. Benjamini and Hochberg's procedure was used to calculate the false discovery rate for multiple comparisons. Results: Higher dietary GL and GI (both based on total and available carbohydrates) and a higher intake of sugar and sugar‐sweetened beverages were associated with lower circulating SHBG concentrations (all P trend < 0.05; Q ‐ values = 0.04, 0.01, 0.07, 0.10, 0.01, and <0.0001, respectively). In contrast, women with a greater intake of dietary fiber tended to have elevated SHBG levels ( P trend = 0.01, Q ‐ value = 0.04). There was no significant association between total carbohydrates or other carbohydrate‐abundant foods and SHBG concentrations. Conclusions: The findings suggest that low GL or GI diets with low sugar and high fiber content may be associated with higher serum SHBG concentrations among postmenopausal women. Future studies investigating whether lower GL or GI diets increase SHBG concentrations are warranted. Abstract : Highlights This large study of postmenopausal women with comprehensive assessment of diet and serum sex hormone‐binding globulin (SHBG) levels indicated that low glycemic load (GL) or glycemic index (GI) and low sugar, but high dietary fiber, were associated with elevated levels of circulating SHBG. The findings support the notion that SHBG may be affected by dietary GL, GI, sugar, and fiber, and may also be an important mediator by which various dietary carbohydrates influence the risk of type 2 diabetes, cardiovascular disease, and hormone‐dependent cancers.