Optogenetic Control of Voltage‐Gated Calcium Channels. (16th April 2018)

• Record Type: Journal Article
• Authors: Ma, Guolin; Liu, Jindou; Ke, Yuepeng; Liu, Xin; Li, Minyong; Wang, Fen; Han, Gang; Huang, Yun; Wang, Youjun; Zhou, Yubin
• Is Part Of: Angewandte Chemie. Volume 130:Number 24(2018)
• Page Start: 7137
• Page End: 7140
• Publication Date: 2018-04-16
• Subjects: Calcium-Signalwege -- Ionenkanäle -- Optogenetik -- Protein-Engineering -- Synthetische Biologie; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201713080
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Voltage‐gated Ca 2+ (CaV ) channels mediate Ca 2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo‐tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV ‐mediated physiological processes.