Laparoscopic Biopsies in Pancreas Transplantation. Issue 8 (4th April 2017)

• Record Type: Journal Article
• Authors: Uva, P. D.; Odorico, J. S.; Giunippero, A.; Cabrera, I. C.; Gallo, A.; Leon, L. R.; Minue, E.; Toniolo, F.; Gonzalez, I.; Chuluyan, E.; Casadei, D. H.
• Is Part Of: American journal of transplantation. Volume 17:Issue 8(2017)
• Page Start: 2173
• Page End: 2177
• Publication Date: 2017-04-04
• Subjects: clinical research/practice -- pancreas/simultaneous pancreas‐kidney transplantation -- biopsy -- rejection; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.14259
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : As there is no precise laboratory test or imaging study for detection of pancreas allograft rejection, there is increasing interest in obtaining pancreas tissue for diagnosis. Pancreas allograft biopsies are most commonly performed percutaneously, transcystoscopically, or endoscopically, yet pancreas transplant surgeons often lack the skills to perform these types of biopsies. We have performed 160 laparoscopic pancreas biopsies in 95 patients. There were 146 simultaneous kidney–pancreas biopsies and 14 pancreas‐only biopsies due to pancreas alone, kidney loss, or extraperitoneal kidney. Biopsies were performed for graft dysfunction (89) or per protocol (71). In 13 cases, an additional laparoscopic procedure was performed at the same operation. The pancreas diagnostic tissue yield was 91.2%; however, the pancreas could not be visualized in eight cases (5%) and in 6 cases the tissue sample was nondiagnostic (3.8%). The kidney tissue yield was 98.6%. There were four patients with intraoperative complications requiring laparotomy (2.5%) with two additional postoperative complications. Half of all these complications were kidney related. There were no episodes of pancreatic enzyme leak and there were no graft losses related to the procedure. We conclude that laparoscopic kidney and pancreas allograft biopsies can be safely performed with very high tissue yields. Abstract : This study describes the technique for laparoscopic pancreas graft biopsies and demonstrates that it can be safely performed with low morbidity and high tissue yields.