Nickel Catalyzed Ipso‐hydroxylation and Subsequent Cross Dehydrogenative Coupling of Arylboronic Acids with Tertiary Amines: A Facile Access to α‐phenolated Tertiary Amines. Issue 9 (25th March 2018)

• Record Type: Journal Article
• Authors: Kumar, Promod; Kumar Sharma, Anup; Singh, Rahul; Guntreddi, Tirumaleswararao; Nand Singh, Krishna
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 9(2018)
• Page Start: 1786
• Page End: 1789
• Publication Date: 2018-03-25
• Subjects: C−H functionalization -- Nickel -- Phenols -- Ipso-hydroxylation -- Tertiary amines; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701625
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A straightforward and new approach has been developed for the α‐functionalization of tertiary amines via sequential oxidative hydoxylation and cross‐dehydrogenative coupling (CDC) of arylboronic acids with tertiary amines to afford α‐phenolated tertiary amines. The results demonstrate an easy arylation of C( sp 3 )−H bond in the presence of an inexpensive and readily available nickel metal salt. Abstract :