Die Behandlung der Psoriasis mit klassischer, stationärer Dithranol‐Therapie: eine retrospektive Patientenbefragung. (29th October 2015)

• Record Type: Journal Article
• Authors: Painsi, Clemens; Patscheider, Michael; Inzinger, Martin; Lange‐Asschenfeldt, Bernhard; Quehenberger, Franz; Wolf, Peter
• Is Part Of: Journal der Deutschen Dermatologischen Gesellschaft. Volume 13:Number 11(2015)
• Page Start: 1156
• Page End: 1164
• Publication Date: 2015-10-29
• Subjects: Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5005
• DOI: 10.1111/ddg.70_12820
• Languages: English
• ISSNs: 1610-0379

Abstract

Summary: Background: Evidence of the efficacy of dithranol and patient perspectives on the treatment is scant. Patients and Methods: Using a telephone interview survey, we collected retrospective data from 63 patients (41 men [65.1 %] and 22 women [34.9 %]) who had been treated with classic inpatient dithranol (CID). PsoRA (www.psoriasisregistry.at) was used to obtain clinical data and treatment responses, which were then correlated with the interview responses. Results: Fifty‐two (82.5 %) patients achieved a PASI75 and 51 (81 %) a PASI90 response within a median of 12.5 (range: 3 to 25) days. Ten out of twelve (83 %) patients showed a satisfactory response to CID (PASI75 or greater reduction) despite the fact that they had previously failed to adequately respond to methotrexate, oral retinoids, cyclosporine, or ustekinumab. Overall, patients recalled a median recurrence‐free interval of four (95 % CI: 3–9) months after responding to CID, which was positively correlated with the patients' recommendation of (p = 0.018) and their overall high satisfaction with the treatment (p = 0.012). Conclusions: Despite the known limitations of CID, this survey indicates that dithranol remains a highly efficacious and valuable treatment option as induction therapy in psoriasis. CID can be effective in patients who have failed to respond to systemic therapy, including traditional agents and biologics.