Effect of pulsatile blood flow on LDL transport in arterial layers. (2018)

• Record Type: Journal Article
• Authors: Santra, Somnath; Mandal, Dipak Kumar; Chakrabarti, Somnath
• Is Part Of: Progress in computational fluid dynamics. Volume 18:Number 3(2018)
• Page Start: 177
• Page End: 187
• Publication Date: 2018
• Subjects: radial filtration velocity -- simple pulsatile profile -- physiological pulsatile profile -- low density lipoprotein -- LDL; Fluid dynamics -- Data processing -- Periodicals; Fluid dynamics -- Mathematics -- Periodicals; 620.10640285
• Languages: English
• ISSNs: 1468-4349

Abstract

Considering the pulsatile nature of blood flow, the transport of low density lipoprotein (LDL) species in the arterial wall has been numerically analysed. A straight axi-symmetric arterial segment with four arterial porous layers vis. endothelium, intima, internal elastic lamina and media has been taken into consideration. These layers are considered porous in nature. For modelling the fluid flow in the lumen and the arterial wall, Navier-Stokes equation and Darcy's equation have been used respectively. The solute flow modelling in the lumen and in the arterial wall has been done by using convection-diffusion equation and convection-diffusion-reaction equation respectively. Simple pulsatile and physiological pulsatile model of blood flow have been considered in the present analysis. The present study shows that the physiological pulsatile flow is having more impact on the radial filtration velocity at lumen-endothelium interface than that of the case for simple pulsatile nature of flow. Therefore, the possibility of enhancement in solute transport in the arterial wall is more in case of physiological pulsatile nature of flow.