Molecular pathology – The value of an integrative approach. Issue 7 (12th August 2014)

• Record Type: Journal Article
• Authors: Salto-Tellez, Manuel; James, Jacqueline A.; Hamilton, Peter W.
• Is Part Of: Molecular oncology. Volume 8:Issue 7(2014:Oct.)
• Page Start: 1163
• Page End: 1168
• Publication Date: 2014-08-12
• Subjects: Molecular pathology -- Molecular diagnostics -- Translational research; Cancer -- Molecular aspects -- Periodicals; 616.994005
• DOI: 10.1016/j.molonc.2014.07.021
• Languages: English
• ISSNs: 1574-7891

Abstract

Abstract : Molecular Pathology (MP) is at the heart of modern diagnostics and translational research, but the controversy on how MP is best developed has not abated. The lack of a proper model or trained pathologists to support the diagnostic and research missions makes MP a rare commodity overall. Here we analyse the scientific and technology areas, in research and diagnostics, which are encompassed by MP of solid tumours; we highlight the broad overlap of technologies and analytical capabilities in tissue research and diagnostics; and we describe an integrated model that rationalizes technical know‐how and pathology talent for both. The model is based on a single, accredited laboratory providing a single standard of high‐quality for biomarker discovery, biomarker validation and molecular diagnostics. Highlights: Modern medicine is dictated by two main developments: molecular medicine and technical advances. Molecular Pathology aims to achieve the integration of a research and diagnostic activities. Academic molecular pathology, at the interface between diagnostics and research, drives such integration. An integrated model has a synergistic effect in molecular diagnostics and translational research.