Iridium‐Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins. Issue 11 (16th April 2018)

• Record Type: Journal Article
• Authors: Yin, Congcong; Wu, Weilong; Hu, Yang; Tan, Xuefeng; You, Cai; Liu, Yuanhua; Chen, Ziyi; Dong, Xiu‐Qin; Zhang, Xumu
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 11(2018)
• Page Start: 2119
• Page End: 2124
• Publication Date: 2018-04-16
• Subjects: Asymmetric hydrogenation -- halogenated ketones -- chiral halohydrins -- enantioselectivity -- chiral tridentate ligand; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800267
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Iridium‐catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram‐scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f‐amphox catalyst with 99% yield and >99% ee. Abstract :