Direct Palladium‐Catalyzed β‐Arylation of Lactams. (5th March 2018)
- Record Type:
- Journal Article
- Title:
- Direct Palladium‐Catalyzed β‐Arylation of Lactams. (5th March 2018)
- Main Title:
- Direct Palladium‐Catalyzed β‐Arylation of Lactams
- Authors:
- Chen, Ming
Liu, Feipeng
Dong, Guangbin - Abstract:
- Abstract: A direct and catalytic method is reported here for β‐arylation of N‐protected lactams with simple aryl iodides. The transformation is enabled by merging soft enolization of lactams, palladium‐catalyzed desaturation, Ar−X bond activation, and aryl conjugate addition. The reaction is operated under mild reaction conditions, is scalable, and is chemoselective. Application of this method to concise syntheses of pharmaceutically relevant compounds is demonstrated.
- Is Part Of:
- Angewandte Chemie. Volume 130:Number 14(2018)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 130:Number 14(2018)
- Issue Display:
- Volume 130, Issue 14 (2018)
- Year:
- 2018
- Volume:
- 130
- Issue:
- 14
- Issue Sort Value:
- 2018-0130-0014-0000
- Page Start:
- 3877
- Page End:
- 3881
- Publication Date:
- 2018-03-05
- Subjects:
- C-H-Aktivierung -- Heterocyclen -- Lactame -- Palladium -- Reaktionsmechanismen
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201800958 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9326.xml