Association between the ratio of triglyceride to high‐density lipoprotein cholesterol and incident type 2 diabetes in Singapore Chinese men and women: 三酰甘油与高密度脂蛋白的比例和新发2型糖尿病的关系:新加坡华人健康研究. (7th October 2016)

• Record Type: Journal Article
• Authors: Wang, Ye‐Li; Koh, Woon‐Puay; Talaei, Mohammad; Yuan, Jian‐Min; Pan, An
• Is Part Of: Journal of diabetes. Volume 9:Number 7(2017)
• Page Start: 689
• Page End: 698
• Publication Date: 2016-10-07
• Subjects: high‐density lipoprotein cholesterol -- nested case–control study -- triglycerides -- type 2 diabetes mellitus; 高密度脂蛋白胆固醇 -- 巢式病例对照研究 -- 三酰甘油 -- 2型糖尿病; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12477
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: Increased triglycerides (TG) and decreased high‐density lipoprotein cholesterol (HDL‐C) are risk factors for type 2 diabetes (T2D). The relationship between TG:HDL‐C ratio and T2D risk is not clear, and it is not known whether the association is modified by gender, body mass index, or fasting status. This study examined the relationship between TG:HDL‐C ratio and risk of incident T2D, and the predictive ability of the ratio on top of other diabetes risk factors. Methods: Blood biomarkers were determined in 571 T2D cases and 571 controls nested within a prospective, population‐based cohort study, the Singapore Chinese Health Study. Participants were free of diagnosed diabetes, cardiovascular disease, and cancer at the time of blood collection (1999–2004). Incident self‐reported T2D cases were identified at follow‐up interview (2006–10). Controls were matched 1: 1 for age, sex, dialect group, and date of blood collection. Multivariable logistic regression was used to compute the odds ratio (OR) and 95 % confidence interval (CI). Results: The ORs (95 % CI) of T2D per 1‐SD increment in TG and TG: HDL‐C ratio were 1.70 (1.39–2.09) and 1.72 (1.37–2.17), respectively. The relationships were stronger among females than males ( P interaction = 0.028 and 0.017, respectively), and stronger among lean (<23 kg/m 2 ) than overweight/obese participants ( P interaction = 0.051 and 0.046, respectively). Both TG and TG: HDL‐C improved T2D prediction to a similar degree. Conclusions: Both TG and TG:HDL‐C ratio are independent risk factors for incident T2D, and confer greater risk in women and lean participants. The TG: HDL‐C ratio is not a better predictor of diabetes than TG alone. Abstract : Summary statistics to evaluate the improved classification of type 2 diabetes by plasma lipid measures Highlights Triglycerides (TG) and the TG: high‐density lipoprotein cholesterol (HDL‐C) ratio was independently associated with increased risk of incident type 2 diabetes (T2D). Both associations were significantly stronger in women and lean participants compared with their counterparts. Both TG and TG: HDL‐C ratio improved T2D prediction to a similar degree. This study conducted formal interaction tests and showed that the association between the TG: HDL‐C ratio and T2D risk was stronger in women and in lean participants. In addition, the usefulness of the TG: HDL‐C ratio to predict T2D is no better than TG alone.