Relationship Between CHA2DS2-VASc Score and Right Ventricular Dysfunction in Patients With Acute Pulmonary Thromboembolism. (December 2018)

• Record Type: Journal Article
• Authors: Gök, Murat; Kurtul, Alparslan; Harman, Murat; Kara, Meryem; Süleymanoglu, Muhammed; Ornek, Ender
• Is Part Of: Clinical and applied thrombosis/hemostasis. Volume 24:Number 9(2018)Supplement
• Page Start: 56S
• Page End: 62S
• Publication Date: 2018-12
• Subjects: CHA2DS2-VASc score -- pulmonary thromboembolism -- right ventricular dysfunction; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 616.13
• DOI: 10.1177/1076029618785771
• Languages: English
• ISSNs: 1076-0296

Abstract

In this study, the association between the right ventricular dysfunction (RVD) and CHA2DS2-VASc (C: congestive heart failure or left ventricular systolic dysfunction, H: hypertension, A: age of ≥ 75 years, D: diabetes mellitus, S: previous stroke, V: vascular disease, A: age between 65 and 74 years, Sc: female gender) scores was investigated in patients with acute pulmonary thromboembolism (PTE). The patients have been assigned to 3 subgroups as massive, submassive, and nonmassive PTE. The CHA2DS2-VASc scores were calculated for all of the patients, and the scores have been classified into 3 groups as the scores between 0 and 1, the scores of 2, and the scores of 3 and over. The independent predictors of the RVD were investigated by the univariate and multivariate regression analyses. The independent predictors of the RVD were determined to be the CHA2DS2-VASc scores ( P = .034), the systolic pulmonary artery pressure ( P < .001), the presence of acute deep vein thrombosis ( P = .007), high simplified Pulmonary Embolism Severity Index ( P < .001), D-dimer ( P < .006), and the mean platelet volume ( P < .001). The CHA2DS2-VASc scores predicted the RVD with 70% sensitivity and 50% specificity as determined by the receiver operating characteristic analysis. The CHA2DS2-VASc score is an independent predictor of the RVD in patients with acute PTE.