Cerebral Small Vessel Disease. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Li, Qian; Yang, Yang; Reis, Cesar; Tao, Tao; Li, Wanwei; Li, Xiaogang; Zhang, John H.
• Is Part Of: Cell transplantation. Volume 27:Issue 12(2018)
• Page Start: 1711
• Page End: 1722
• Publication Date: 2018-12
• Subjects: Cerebral small vessel disease -- arteriolosclerosis -- cerebral amyloid angiopathy -- neuroimaging -- MRI -- stroke syndrome -- dementia; Cell transplantation -- Periodicals; Cell Transplantation; Cell transplantation; Electronic journals; Periodicals; Periodicals; 571.638
• DOI: 10.1177/0963689718795148
• Languages: English
• ISSNs: 0963-6897

Abstract

Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The main clinical manifestations of CSVD include stroke, cognitive decline, dementia, psychiatric disorders, abnormal gait, and urinary incontinence. Currently, there are no specific preventive or therapeutic measures to improve this condition. In this review, we will discuss the pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease.