Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values. Issue 1 (13th January 2014)

• Record Type: Journal Article
• Authors: Peel, Amanda B.; Thomas, Samantha M.; Dittus, Kim; Jones, Lee W.; Lakoski, Susan G.
• Is Part Of: Journal of the American Heart Association. Volume 3:Issue 1(2014:Feb.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-01-13
• Subjects: breast cancer -- cardiorespiratory fitness -- women; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.113.000432
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: There is emerging evidence that adjuvant treatments for breast cancer negatively impact cardiorespiratory fitness (CRF) orVo 2max, a key predictor of cardiovascular risk. Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding expected CRF values in this patient population. Given that CRF is a poor prognostic sign and recently highlighted as a key measure to standardize by the American Heart Association, we sought to review the available literature on CRF among breast cancer patients. Methods and Results: We identified 27 clinical trials and observational studies measuringVo 2max in the pre– and post–adjuvant treatment setting for breast cancer. We comparedVo 2max before toVo 2max after adjuvant therapy and comparedVo 2max in female breast cancer patients withVo 2max in healthy controls. Conclusions: We found that CRF was substantially lower in women with a history of breast cancer compared with healthy women and this was most pronounced among breast cancer patients in the post‐adjuvant setting. We conclude that knowledge of normative CRF values is critical to tailor appropriately timed exercise interventions in breast cancer patients susceptible to low CRF and subsequent cardiovascular risk.