Concomitant neoplasms in the skin and stomach unveil the role of type IV collagen and E‐cadherin in mucin core protein 5AC expression in vivo. (8th November 2015)

• Record Type: Journal Article
• Authors: Hata, H.; Natsuga, K.; Kitamura, S.; Imafuku, K.; Yamaguchi, Y.; Ebihara, Y.; Shichinohe, T.; Hirano, S.; Shimizu, H.
• Is Part Of: British journal of dermatology. Volume 174:Number 2(2016)
• Page Start: 395
• Page End: 397
• Publication Date: 2015-11-08
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.14084
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Mucin core protein (MUC) 5AC is a gel‐forming glycoprotein that is expressed in different types of tumour cells. MUC5AC expression in cultured cells is regulated through the extracellular matrix and through remodelling by other membranous proteins such as type IV collagen (COL4) and E‐cadherin. However, it has not been elucidated whether COL4 and E‐cadherin affect MUC5AC expression in tumours in vivo . Here, by analysing a single individual with concomitant neoplasms in the skin [extramammary Paget disease (EMPD)] and the stomach (gastric cancer), we show that MUC5AC expression is reduced in COL4 and membranous E‐cadherin‐expressing EMPD specimens whereas MUC5AC is not abolished in gastric cancer with COL4 negativity and E‐cadherin cytoplasmic localization. As the EMPD and gastric cancer specimens were derived from a single patient, each specimen had the same genetic background. These in vivo results support previous in vitro studies which showed that COL4 and E‐cadherin downregulated MUC5AC expression. Our study suggests that concomitant neoplasms in different organs of the same individual can serve as a strong tool for uncovering functional diversity in tumour markers in distinct cancer cells. Abstract : What's already known about this topic? Type IV collagen (COL4), a major component of the basal lamina, and E‐cadherin were shown to downregulate MUC5AC expression in cultured cells. What does this study add? We demonstrate that MUC5AC expression may be regulated by COL4 and E‐cadherin in vivo for the first time.