Mitochondrial DNA haplogroups influence the risk of aortic stenosis. (January 2019)

• Record Type: Journal Article
• Authors: Serrano-Teruel, Maria E.; Garcia-Vieites, Maria; Rego-Perez, Ignacio; Domenech-Garcia, Nieves; Blanco-Garcia, Francisco; Cuenca-Castillo, Jose J.; Bautista-Hernandez, Victor
• Is Part Of: Asian cardiovascular & thoracic annals. Volume 27:Number 1(2019)
• Page Start: 5
• Page End: 10
• Publication Date: 2019-01
• Subjects: Aortic valve stenosis -- DNA -- mitochondrial -- Genetic predisposition to disease -- Haplotypes -- Risk factors; Heart -- Diseases -- Asia -- Periodicals; Heart -- Diseases -- Pacific Area -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Surgery -- Asia -- Periodicals; Heart -- Surgery -- Pacific Area -- Periodicals; Heart -- Surgery -- Periodicals; Chest -- Surgery -- Asia -- Periodicals; Chest -- Surgery -- Pacific Area -- Periodicals; Chest -- Surgery -- Periodicals; 617.412
• DOI: 10.1177/0218492318813220
• Languages: English
• ISSNs: 0218-4923

Abstract

Aim: The underlying pathophysiologic mechanisms of aortic stenosis are not clear. Mitochondrial dysfunction plays a role in many pathological conditions including cardiac diseases. We aimed to analyze the mitochondrial DNA haplogroups in a group of patients undergoing valve replacement surgery due to severe aortic stenosis. Methods: Mitochondrial DNA haplogroups were assessed in 176 patients with severe aortic stenosis and 308 control subjects. Cardiovascular risk factors and demographics were similar in both groups. Results: Patients carrying haplogroup Uk had a lower risk of developing aortic stenosis, especially compared to patients carrying haplogroup H (odds ratio = 0.507; 95% confidence interval: 0.270–0.952, p = 0.035). Conclusions: Mitochondrial DNA haplogroups could be involved in the development of severe aortic stenosis. Specifically, haplogroup H could be a risk factor and Uk a protective factor for severe aortic stenosis in a population from Spain.