Cover Feature: Pressure‐Induced Dissolution and Reentrant Formation of Condensed, Liquid–Liquid Phase‐Separated Elastomeric α‐Elastin (Chem. Eur. J. 33/2018). Issue 33 (29th May 2018)

• Record Type: Journal Article
• Authors: Cinar, Hasan; Cinar, Süleyman; Chan, Hue Sun; Winter, Roland
• Is Part Of: Chemistry. Volume 24:Issue 33(2018)
• Page Start: 8242
• Page End: 8242
• Publication Date: 2018-05-29
• Subjects: elastin -- high-pressure chemistry -- intrinsically disordered proteins -- liquid–liquid phase separation -- protein–protein interactions; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201802505
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Liquid–liquid phase separation appears to play an important role in the membraneless compartmentalization of cells and possibly also in the development of prebiotic cells, which might have evolved in the deep sea. This work shows how high hydrostatic pressures modify the mesoscopic structure of condensates comprised of α‐elastin. A novel pressure‐induced reentrant phase separation was observed in the intermediate temperature range. More information can be found in the Communication by R. Winter et al. onpage 8286 .