Frontispiece: Synthesis of Highly Substituted 1, 2‐Diazetidin‐3‐ones, Small‐Ring Scaffolds for Drug Discovery. Issue 33 (14th June 2018)

• Record Type: Journal Article
• Authors: Santos, Marilia S.; Nortcliffe, Andrew; Lewis, William; Bradshaw, Tracey D.; Moody, Christopher J.
• Is Part Of: Chemistry. Volume 24:Issue 33(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-14
• Subjects: 4-membered rings -- carbene insertion -- drug discovery -- heterocycles -- lead-oriented synthesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201883365
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : 1, 2‐Diazetidin‐3‐ones remain an under‐investigated small‐ring heterocycle. Nevertheless their diverse structures offer the potential to explore chemical space as illustrated by the principal moments of inertia "triangle" in rod‐like (rocket), sphere‐like (planet) and disc‐like (flying saucer) regions. Inspired by the unexpected three‐dimensionality of substituted 1, 2‐diazetidin‐3‐ones, the synthesis and functionalization of a range of these strained four‐membered rings are reported; for more details, see Full Paper by C. J. Moody et al. onpage 8325 ff.